Saturday, February 1, 2014

Empty Capsule Shell Weight & Capsule fill volume / weight capacity according to the density of the powder.


Dimensional Specification:
The following specifications apply to Capsugel hard gelatin capsules.

Weight:
The average capsule weight of an order is estimated by a representative sample average of 100 capsules falling within the limits given bellow:
(values in mg for one capsules)
Size
Target (mg)
Limits (mg)
000
163
150 – 176
00
122
112 – 132
0 el
112
103 – 121
0
96
86 – 105
1
77
69 – 85
2
62
56 – 68
3
49
44 – 54
4
39
36 – 44
5
27
24 - 36
A moisture content of 14% to 14.5% is assumed upper and lower limits are given at the 99.9% confidence level.
In empty hard gelatin capsule production wall thickness is carefully monitored and controlled by the regulation of gelatin solution viscosity. However, since the physical properties of raw gelatin are not constant. Solution density may vary and affect the resultant capsule weight. Therefore the above target weight should not be used as tare weights in capsule filling samples from the actual batch being filled should be taken as tare weights.

Capsule capacity:
The average capsule volume and filled capsule weight capacity for typical powder dose densities is as follows:
Capsule Size
Capsule Volume ML of Water
Capsule weight capacity in mg
Powder dose density
0.6 g/cc
0.8 g/cc
1.0 g/cc
1.2 g/cc
000
1.37
822
1096
1370
1644
00
0.95
520
760
950
1140
0 el
0.78
458
624
780
936
0
0.68
408
544
680
816
1
0.50
300
400
500
600
2
0.37
222
296
370
444
3
0.30
180
240
300
360
4
0.21
126
168
210
252
5
0.13
78
104
130
156
















The above data are to be considered as approximations since filling product variables and filling machine type can significantly affect the capsule weight capacity.


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