Friability of Tablets.

Friability

Friability is defined as a percent (%) reduction in the mass of the tablets, occurring when the tablets are subjected to mechanical strain during handling.

For tablets with a unit mass equal to or less than 650 mg, take a sample of whole  tablets corresponding as near as possible to 6.5 g. For tablets with a unit mass of more than 650 mg, take a sample of 10 whole tablets. The tablets are carefully dedusted prior to testing. Accurately weigh the tablet sample, and place the tablets in the drum. Rotate the drum 100 times, and remove the tablets. Remove any loose dust from the tablets as before, and accurately weigh.

Drum RPM: 25

Time: 4 minutes

                       Initial Weight – Final Weight

Calculation = --------------------------------------   x   100

                                    Initial Weight

  Friability   =       %

Source: BP 2013