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Tuesday, May 14, 2013
Friability of Tablets.
Friability
Friability
is defined as a percent (%) reduction in the mass of the tablets, occurring
when the tablets are subjected to mechanical strain during handling.
For
tablets with a unit mass equal to or
less than 650 mg, take a sample of whole
tablets corresponding as near as
possible to 6.5 g. For tablets with a unit mass of more than 650 mg, take a sample of 10 whole tablets. The tablets
are carefully dedusted prior to testing. Accurately weigh the tablet sample,
and place the tablets in the drum. Rotate the drum 100 times, and remove the tablets. Remove any loose dust from the
tablets as before, and accurately weigh.
Drum
RPM: 25
Time:
4 minutes
Initial Weight – Final
Weight
Calculation =
--------------------------------------
x 100
Initial
Weight
Friability = %
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