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Saturday, March 23, 2013
Free Download of TEXTBOOK OF MEDICAL PHYSIOLOGY pdf e-book (11th Edition). Edited By GUYTON & HALL
Free Download of TEXTBOOK OF MEDICAL PHYSIOLOGY pdf e-book (11th Edition). Edited By GUYTON & HALL To download this book click on the following image or link:
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Free Download of Ganong`s Review Of Medical Physiology pdf e-book (23rd Edition).
Free Download of Ganong`s Review Of Medical Physiology pdf e-book (23rd Edition). To download this book click on the following image or link:
Size: 32.9 MB
Free Download of Human anatomy pdf e-book. Edited By VAN DE GRAAFF.
Free Download of Human anatomy pdf e-book. Edited By VAN DE GRAAFF. To download this book click on the following image or link:
Size: 105 MB
Free Download of Essential Medical Physiology pdf e-book (Third Edition). Edited By Leonard R. Johnson.
Free Download of Essential Medical Physiology pdf e-book (Third Edition). Edited By Leonard R. Johnson. To download this book click on the following image or link:
Size: 16.6 MB
Friday, March 22, 2013
Fumigation Method for Pest Control Used in Aseptic Area
Fumigation:
Fumigation is a method of pest
control that completely fills an area with gaseous pesticides or fumigants
to suffocate or poison the pests within. It is utilized for control of pests.
Process:
Fumigation usually involves the following phases: First the area to be
fumigated is cleaned and disinfected as per SOP Clean up of Aseptic
Area. Next the fumigant (40
% formaldehyde solution is widely used as fumigant) is released (create fume by heating the
solution with a heater) into the space to be fumigated. After completely
evaporation of formaldehyde
solution the space is held for a
set period (eg. 6 hours) while the fumigant gas percolates through the space
and acts on and kills any infestation in the product, next the space is
ventilated so that the poisonous gases are allowed to escape from the space,
and render it safe for humans to enter.
Preparation of Fumigation Solution:
Prescription: Use formaldehyde at the rate of 2.5-mg/ liter volume space. [1litre
º 0.03531466 cft]
Take the required
quantity of 40 % formalin according to the prescription and add 25 %
distilled water to make the stock solution.
Calculation:
40 % commercial formalin i.e.,
100ml contains 40gm of formaldehyde.
2.5
1 cft require = mg of
Formaldehyde
0.03531466
2.5 x V
V cft require = mg
of Formaldehyde
= 70.792V
mg = 0.070792V gm
40 gm Formaldehyde from 100ml
Commercial formalin
1 gm ,, ,, ml Commercial formalin
40
40
= 0.17698 V ml commercial
formalin
|
Parameters and Specification of Dissolution & Disintegration of Tablets
Tablets (Disintegration & Dissolution)
Tablets
are solid preparations each containing a single dose of one or more
active substances. They are obtained
by compressing uniform volumes of particles or by another suitable manufacturing technique,
such as extrusion, moulding or freeze- drying (lyophilisation). Tablets are
intended for oral administration. Some are
swallowed whole, some after being chewed, some are dissolved or
dispersed in water before being
administered and some are retained in the mouth where the active substance is liberated.
The
particles consist of one or more active substances with or without
excipients such as diluents, binders,
disintegrating agents, glidants, lubricants, substances capable of modifying the behaviour of the
preparation in the digestive tract, colouring
matter authorised by the competent authority and flavouring
substances.
Several categories of
tablets for oral use may be distinguished:
·
uncoated tablets;
·
coated tablets;
·
effervescent
tablets;
·
soluble tablets;
·
dispersible tablets;
·
orodispersible tablets;
·
gastro-resistant tablets;
·
modified-release tablets;
·
tablets for use in the mouth;
·
oral lyophilisates.
|
Disintegration:
Type of Tablet
|
Media
|
Specification
|
For Out of
Specification
|
UNCOATED
TABLETS
|
Water (37°C ± 2°C)
|
Not
More Than 15 minutes with disc
|
Repeat
the test on a further 6 Tablets
|
Film-coated Tablets
|
Water (37°C ± 2°C)
|
Not
More Than 30 minutes with disc
|
Repeat
the test on a further 6 Tablets
|
Enteric Coated Tablets
|
0.1 M hydrochloric
acid without disc (37°C ± 2°C)
(after
2 hours replace 0.1 M HCl Solution with the phosphate buffer)
|
2
hours remains intake
|
Repeat
the test on a further 6 Tablets
|
phosphate buffer solution
pH 6.8 (with disc) (37°C ± 2°C)
|
Not More Than 60 minutes
with disc
|
||
Effervescent Tablet
|
200 ml Water (15-25 °C)
|
Not
More Than 5 minutes
|
Repeat
the test on a further 5 Tablets
|
Soluble Tablet
|
Water (15-25 °C)
|
Not
More Than 3 minutes
|
Repeat
the test on a further 6 Tablets
|
Dispersible Tablets
|
Water (15-25 °C)
|
Not
More Than 3 minutes
|
-------
|
Orodispersible Tablets
|
------
|
Not
More Than 3 minutes
|
------
|
Dissolution:
Four types of apparatuses
are now described in the British and European Pharmacopoeias; the basket, the paddle, the reciprocating
cylinder and the flow-through
cell. The descriptions are concordant with those published in the United
States Pharmacopeia (USP).
Of the
two established apparatuses (basket
and paddle) the paddle is now the apparatus of choice for many
preparations. However, where a published test uses the basket, work to
validate a change to the paddle method is not contemplated. The reciprocating
cylinder is useful for pH profiling studies while the flow-through cell may
be appropriate for preparations of poorly soluble active ingredients (see
Annex).
Test conditions The harmonised test conditions included in Appendix XII B1 will be applied to
all new monographs of the British Pharmacopoeia. It is not the intention of
the British Pharmacopoeia Commission to apply these criteria retrospectively
to existing monographs. Where an individual monograph prescribes the use of
the requirements stated under Monographs of the British Pharmacopoeia
in Appendix XII B1, the following conditions using the basket or paddle
apparatus are preferred.
Ø
rotation speed:100 rpm (basket), 50 rpm (paddle)
Ø
dissolution medium volume: 900 ml
Ø
dissolution medium composition: aqueous, commonly
0.1M hydrochloric acid or phosphate buffers of pH 6.8 to 7.6
Ø
number of units tested: 6 (plus 6, if a retest is required).
The
number of units tested is specified in Appendix XII B1; other conditions are
specified in the relevant individual monographs.
In
situations where it has been demonstrated that the harmonised criteria are
not applicable (e.g. low solubility preparations, 'coning' of material in the
vessel, low concentration of analyte), modifications may be made to the test
conditions, such as, adding a surfactant, increasing the paddle rotation
speed or using a modified vessel and reducing the volume of dissolution
medium used.
|
Dissolution:
Type of Tablet
|
Media
|
Specification
|
For Out of
Specification
|
UNCOATED
TABLETS
|
0.1 M hydrochloric acid / phosphate
buffer solution / Water (37°C ± 0.5°C)
|
Should not be released
less than 70% of labeled amount at 45 minutes
|
Repeat
the test on a further 6 Tablets
|
Film-coated Tablets
|
0.1 M hydrochloric acid / phosphate
buffer solution / Water(37°C ± 0.5°C)
|
Should not be released
less than 70% of labeled amount at 45 minutes
|
Repeat
the test on a further 6 Tablets
|
Enteric Coated Tablets
|
(media for 2 hours)
0.1 M hydrochloric acid (37°C ± 0.5°C)
|
Should
not be released more than 10% of labeled amount after 2 hours
|
Repeat
the test on a further 6 Tablets
|
Then
replace the 0.1 M HCl by phosphate
buffer
solution pH 6.8 (37°C ± 0.5°C)
|
Should
not be released less than 70% of labeled amount at 45 minutes
|
Source: BP 2013
Thursday, March 21, 2013
Free Download of Nanoparticulates as Drug Carriers pdf e-book. Edited By Vladimir P Torchilin.
Free Download of Nanoparticulates as Drug Carriers pdf e-book. Edited By Vladimir P Torchilin. To Download this e-book click on the following image or link:
Size: 49.79 MB
Free Download of Methods of Analysis For Functional Foods and Nutraceuticals pdf e-book. Edited By W. Jeffrey Hurst.
Free Download of Methods of Analysis For Functional Foods and Nutraceuticals pdf e-book. Edited By W. Jeffrey Hurst. To Download this e-book click on the following image or link:
Size: 4.12 MB
Free Download of Managing The Analytical Laboratory pdf e-book. Edited By Clifford L. Nilsen.
Free Download of Managing The Analytical Laboratory pdf e-book. Edited By Clifford L. Nilsen. To Download this e-book click on the following image or link:
Size: 10.66 MB
Free Download of Liposome Technology Entrapment of Drugs and Other Materials Into Liposomes (Third Edition) pdf e-book. Edited By Gregory Gregoriadis.
Free Download of Liposome Technology Entrapment of Drugs and Other Materials Into Liposomes (Third Edition) pdf e-book. Edited By Gregory Gregoriadis. To Download this e-book click on the following image or link:
Size: 10.35 MB
Free Download of Hospital Pre-registration Handbook
Free Download of Hospital Pre-registration Handbook pdf e-book. To Download this e-book click on the following image or link:
Size: 10.12 MB
Free Download of Good Manufacturing Practices For Pharmaceuticals (Sixth Edition) pdf e-book. Edited By Josheph D. Nally. To Download this e-book click on the following image or link:
Free Download of Good Manufacturing Practices For Pharmaceuticals (Sixth Edition) pdf e-book. Edited By Josheph D. Nally. To Download this e-book click on the following image or link:
Size: 5.26 MB
Free Download of Handbook of Aqueous Solubility Data pdf e-book. Edited By Samuel H. Yalkowsky & Yan He.
Free Download of Handbook of Aqueous Solubility Data pdf e-book. Edited By Samuel H. Yalkowsky & Yan He. To Download this e-book click on the following image or link:
Size: 3.34 MB
Free Download of Fundamental Immunology (Fift Edition) pdf e-book. Edited By William E. Paul.
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Size: 13.34 MB
Free Download of Atlas of Selective Sentinel Lymphadenectomy for Melanoma Breast Cancer and Colon Cancer pdf e-book. Edited By Stanely P.L. Leong.
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Size: 3.45 MB
Free Download of Drug Delivery to The Oral Cavity Molecules to Market pdf e-book. Edited By Tapash K Gosh & William R Pfister.
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Size: 6.86 MB
Free Download of Essential Statics For The Pharmaceutical Sciences pdf e-book. Edited By Philip Rowe.
Free Download of Essential Statics For The Pharmaceutical Sciences pdf e-book. Edited By Philip Rowe. To Download this e-book click on the following image or link:
Size: 2.71 MB
Free Download of Dictionary of Medical Acronyms & Abbreviations ( Fifth Edition) pdf e-book.
Free Download of Dictionary of Medical Acronyms & Abbreviations ( Fifth Edition) pdf e-book. To Download this e-book click on the following image or link:
Free Download of A Textbook of Modern Toxicology (Third Edition) pdf e-book. Edited By Ernest Hodgson.
Free Download of A Textbook of Modern Toxicology (Third Edition) pdf e-book. Edited By Ernest Hodgson. To Download this e-book click on the following image or link:
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Size: 4.14 MB
Free Download of Active Pharmaceutical Ingredients Development, Manufacturing and Regulation pdf e-book. Edited By Stanely H. Nusim.
Free Download of Active Pharmaceutical Ingredients Development, Manufacturing and Regulation pdf e-book. Edited By Stanely H. Nusim. To Download this e-book click on the following image or link:
Size: 3.45 MB
Monday, March 18, 2013
The Principle of Toxicology (Second Edition) pdf e-book Free Download. Edited By Phillip L. Williams, Rober C. James & Stephen M. Roberts.
The Principle of Toxicology (Second Edition) pdf e-book Free Download. Edited By Phillip L. Williams, Rober C. James & Stephen M. Roberts. To Download this e-book click on the following image or link:
Size: 7.93 MB
Sunday, March 17, 2013
Free Download of Nanoparticulate Drug Delivery Systems pdf e-book. Edited By Deepak Thassu, Michel Deleers Yashwant Pathak.
Free Download of Nanoparticulate Drug Delivery Systems pdf e-book. Edited By Deepak Thassu, Michel Deleers Yashwant Pathak. To download this book click on the following image or link:
Size: 6.84 MB
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